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Department of Pharmacology and Toxicology

Irena Zemenová
377 593 240
Department staff >

The department is located in the new building of the University Medical Center, together with other preclinical disciplines, in close proximity to the Pilsen – Lochotín Faculty Hospital. The head of the Department of Pharmacology and Toxicology is prof. PharmDr. Radek Kučera, Ph.D.

Consulting hours

prof. PharmDr, Radek Kučera, Ph.D.
PharmDr. Eva Dědečková                                
MUDr. Michal Jirásko
by agreement

Post address:
Faculty of Medicine in Pilsen, Charles University
Department of Pharmacology and Toxicology
alej Svobody 1655/76, building U2, 323 00 Pilsen


General Information

The Department of Pharmacology and Toxicology provides courses in medical pharmacology in the third and fourth year of Master’s degree in general and dental medicine in Czech and English language. Lectures are held in seminars at UNIMEC (the new building of the University Medical Center).

Teachers are authors, co-authors and reviewers of the script and a nationwide textbook for pharmacologists. The workplace is involved in the creation of e-learning teaching materials within the framework of the cooperation of the Czech medical faculties in the MEFANET educational network of Czech and Slovak physicians, which aims to modernize the teaching of medical and health care disciplines.

LFP students are also using the Moodle e-learning portal in both semesters. In both seminar rooms there are computers for students. PC programs have been purchased and updated from funding tools to simulate the pharmacological effects of substances and evaluate drug levels in the human body. The programs are suitable for undergraduate and postgraduate students.




The Department of Pharmacology and Toxicology of the Faculty of Medicine of the Charles University in Pilsen has been long studying the effects of certain environmental pollutants (especially heavy metals, metalloids and substances that would protect the organism from their harmful effects and facilitate their elimination). In the last few years, the experimental program is focused on study of oxidative stress as one of the most important factors of metal toxicity. The staff of the department is looking for substances that would protect organisms from the effects of heavy metals or directly prevent oxidative damage to tissues (eg liver, kidneys). We study chelating agents and especially substances of natural origin (resveratrol, quercetin, curcumin, sesquiterpenic lactones, etc.) Intoxication, oxidative stress and newly changes in the immune system are studied at the cellular and organ levels. The workplace is materially equipped to monitor pharmacokinetic parameters (analytical methods HPLC, AAS), biochemical analyzes of oxidative damage (spectrometry). In the new UNIMEC building, we have created spaces for working with cell lines and for molecular methods (PCR, Western blotting).