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Department of Pathophysiology
About
The department provides undergraduate and postgraduate education and is focused on neuroscience research. Undergraduate teaching of pathological physiology in Czech and English applies to students of the 2nd and 3rd year of general medicine and 3rd year of dental medicine. For motivated students, the department offers core elective subjects and the opportunity to participate in research projects and present the results at student conferences.
Pathological physiology I (2025)
Pathological physiology I takes place in summer semester for students of 2nd year of general medicine.
Syllabus
Goals of teaching
Lectures
Practicals
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class with the sanction of absence.
Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.
Credit
Conditions for the credit – Pathological physiology I:
Active attending practical exercises – 2 absences per semester are allowed.
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology I follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.
Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.
Students who have the subject enrolled repeatedly must also fulfill the conditions for credit in full.
Note:
Pathological physiology I is followed by pathological physiology II ending with a credit and exam.
Educational materials
Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.
Literature
Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathological Physiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the website of the department or provided to students in printed or electronic form.
Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue
Pathological physiology II (2025)
Subsequent subject Pathological physiology II takes place in winter semester and is designed for students of 3rd year of general medicine.
Syllabus
Goals of teaching
Lectures
Practicals
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class.
Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology, pathological physiology I.
Credit
Conditions for the credit – Pathological physiology II:
- Active attending practical exercises – 2 absences per semester are allowed.
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology II follows, i.e. pathological physiology I, anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class. - Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.
Students who have the subject enrolled repeatedly must also fulfill the conditions for credit in full.
Exam
Conditions for the exam:
The condition for registration for the exam is to obtain a credit in pathological physiology I and pathological physiology II, if not set differently for a specific term.
The student is obliged to register for the exam using SIS (other ways of registration will not be accepted) within the deadline specified in SIS for the given exam date. Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination. The condition for registration for the exam is to obtain a credit (if not specified differently for a particular exam date). For exam dates, the impossibility of registering if less than 5 days before this date the student’s regular or 1st re-examination term was classified “fail” can be set. Some exam dates can be limited to regular examination, the 1st re-examination or the 2nd re-examination.
Pathological physiology II follows pathological physiology I. The required knowledge contains curriculum of both subjects pathological physiology I and pathological physiology II. Knowledge of other subjects to which pathological physiology follows is also necessary (see syllabus).
The required knowledge is based on the list of exam questions, the syllabi and goals of teaching of the subjects Pathological Physiology I and Pathological Physiology II.
The exam consists of a practical exam and oral exam.
Practical exam consists of 1 question and description, diagnosis and pathophysiological analysis of 3 ECG records. Failure in the practical exam means classification of the exam “fail”.
Oral exam consists of 4 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 4 questions.
Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.
Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam “failed”, the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.
During preparation for the exam, from the moment the first exam question is given, or during the exam itself, students are not allowed to use or carry any electronic devices, including mobile phones, or text or other study materials and aids, except for tools and material provided by the teacher for the purposes of the practical exam. From the moment of giving the first question, during the subsequent preparation and during the exam itself, students are not allowed to leave the room. To prepare for the exam, the student has 30 minutes from the time the questions are given. During the preparation, the student can write notes only on a paper and with a pencil, which are provided to the student by a staff member of the Department of Pathological Physiology. It is not allowed to carry any other paper or notepad.
Due to capacity reasons, the exam can be divided into several days within the given exam date. Students are required to attend the appropriate stage of the exam according to the schedule or examiner’s instructions.
Educational materials
Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.
Literature
Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathological Physiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the website of the department or provided to students in printed or electronic form.
Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue
Pathological physiology I (2024)
Pathological physiology I takes place in summer semester for students of 2nd year of general medicine.
Syllabus
Goals of teaching
Lectures
Practicals
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class with the sanction of absence.
Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.
Credit
Conditions for the credit – Pathological physiology I:
1. Active attending practical exercises – 2 absences per semester are allowed.
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology I follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.
2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.
Note:
Pathological physiology I is followed by pathological physiology II ending with a credit and exam.
Educational materials
Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.
Literature
Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathophysiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the webpage of the department or provided to students in printed or electronic form.
Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue
Pathological physiology II (2024)
Subsequent subject Pathological physiology II takes place in winter semester 2024/2025 and is designed for students of 3rd year of general medicine.
Syllabus
Goals of teaching
Lectures
Practicals
Requirements
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class.
Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology, pathological physiology I.
Pathological physiology II – timetable
Pathological physiology II – programme of practical exercises
Credit
Conditions for the credit – Pathological physiology II:
1. Active attending practical exercises – 2 absences per semester are allowed.
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology II follows, i.e. pathological physiology I, anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.
2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.
Exam
Conditions for the exam:
The condition for registration for the exam is to obtain a credit in pathological physiology I and pathological physiology II, if not set differently for a specific term.
The student is obliged to register for the exam using SIS (other ways of registration will not be accepted) within the deadline specified in SIS for the given exam date. Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination. The condition for registration for the exam is to obtain a credit (if not specified differently for a particular exam date). For exam dates, the impossibility of registering if less than 5 days before this date the student’s regular or 1st re-examination term was classified “fail” can be set. Some exam dates can be limited to regular examination, the 1st re-examination or the 2nd re-examination.
Pathological physiology II follows pathological physiology I. The required knowledge contains curriculum of both subjects pathological physiology I and pathological physiology II. Knowledge of other subjects to which pathological physiology follows is also necessary (see syllabus).
The required knowledge is based on the list of exam questions, the syllabi and goals of teaching of the subjects Pathological Physiology I and Pathological Physiology II.
The exam consists of a practical exam and oral exam.
Practical exam consists of 1 question and description, diagnosis and pathophysiological analysis of 3 ECG records. Failure in the practical exam means classification of the exam “fail”.
Oral exam consists of 4 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 4 questions.
Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.
Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam “failed”, the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.
During preparation for the exam, from the moment the first exam question is given, or during the exam itself, students are not allowed to use or carry any electronic devices, including mobile phones, or text or other study materials and aids, except for tools and material provided by the teacher for the purposes of the practical exam. From the moment of giving the first question, during the subsequent preparation and during the exam itself, students are not allowed to leave the room. To prepare for the exam, the student has 30 minutes from the time the questions are given. During the preparation, the student can write notes only on a paper and with a pencil, which are provided to the student by a staff member of the Department of Pathological Physiology. It is not allowed to carry any other paper or notepad.
Due to capacity reasons, the exam can be divided into several days within the given exam date. Students are required to attend the appropriate stage of the exam according to the schedule or examiner’s instructions.
Educational materials
Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.
Literature
Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathological Physiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the website of the department or provided to students in printed or electronic form.
Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue
Dental Medicine
Syllabus
Lectures
Practicals
Practicals
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class with the sanction of absence.
Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.
Credit
Conditions for the credit :
1. Active attending practical exercises – 1 absence per semester are allowed.
For the practical exercises or seminars, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (se study literature). Students, who did not attend the class in time, will be not admitted to the class.
2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.
Students who have the subject enrolled repeatedly must also fulfill the conditions for credit in full.
Exam
Conditions for the exam:
The student is obliged to register for the exam using SIS (other ways of registration will not be accepted) within the deadline specified in SIS for the given exam date. Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination. The condition for registration for the exam is to obtain a credit (if not specified differently for a particular exam date). For exam dates, the impossibility of registering if less than 5 days before this date the student’s regular or 1st re-examination term was classified “fail” can be set. Some exam dates can be limited to regular examination, the 1st re-examination or the 2nd re-examination.
The required knowledge is based on the list of exam questions, the syllabus of the subject, and goals of teaching. Knowledge of other subjects to which pathological physiology follows (see syllabus) is also necessary.
The exam consists of a practical exam and oral exam.
Practical exam consists of question related to practical exercises. Failure in the practical exam means classification of the exam “fail”.
Oral exam consists of 3 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 3 questions.
Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.
Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam “failed”, the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.
During preparation for the exam, from the moment the first exam question is given, or during the exam itself, students are not allowed to use or carry any electronic devices, including mobile phones, or text or other study materials and aids, except for tools and material provided by the teacher for the purposes of the practical exam. From the moment of giving the first question, during the subsequent preparation and during the exam itself, students are not allowed to leave the room. To prepare for the exam, the student has 30 minutes from the time the questions are given. During the preparation, the student can write notes only on a paper and with a pencil, which are provided to the student by a staff member of the Department of Pathological Physiology. It is not allowed to carry any other paper or notepad.
Due to capacity reasons, the exam can be divided into several days within the given exam date. Students are required to attend the appropriate stage of the exam according to the schedule or examiner’s instructions.
Educational materials
Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathophysiology – dental and also in the course Pathological Physiology I, II which is primarily intended for general medicine students. It is possible to register for the course via a CAS account.
Literature
Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathological Physiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the webpage of the department or provided to students in printed or electronic form.
Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue
Core elective subject
Brain – mechanisms and pathophysiology of its higher functions
Abstract:
You’ll learn about mechanisms of higher cognitive functions of the brain – learning and memory, sensory information processing, decision making, etc. The main impact of the course is on experimental neuroscience across its cellular and systems levels, and both on its basic and most recent achievements. Despite we’ll always look for the relevant clinical projections, the primary focus is scientific. The seminar will mainly build on your previous knowledges in neuroanatomy and neurophysiology.
Guarantor: Ježek Karel, M.D., Ph.D.
Literature:
Principles of Neural Science, Kandel et al., McGraw-Hill Education / Medical, 2012
Research
After the founding of the faculty in 1945, the activities of the staff of the institute consisted almost exclusively of teaching. From the beginning of the 1950s, research activities focused on higher nervous activity were started, and thus the future scientific profiling of the institute focused on experimental research of the nervous system was determined. Since the mid-1990s, research has focused on the pathophysiology of the cerebellum.
At present, the central point of the research focus remains the issue of cerebellar degeneration. Using several mouse models and more experimental approaches (behavioral, electrophysiological, histological, histo- and immunohistochemical methods), not only the pathogenetic mechanisms of these processes in various conditions (stress factors, enriched environment) are studied, but there is also an effort to find ways to influence them, for example with neuropharmaceuticals, growth factors and neurotransplantation. As part of this research, there is a long-term cooperation with a number of domestic and foreign laboratories. In recent years, the research activities of the department are linked with the scientific activities of the Biomedical Center.
Contact
Department of Pathophysiology
Charles University
Faculty of Medicine in Pilsen
alej Svobody 1655/76, building U2
32300 Pilsen
tel: + 420 377 593 360
e-mail: andrea.korandova@lfp.cuni.cz