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Department of Pathophysiology

About

The Department of Pathophysiology, Faculty of Medicine in Pilsen, Charles University provides undergraduate and postgraduate education and is focused on neuroscience research.
Undergraduate teaching of pathological physiology in Czech and English applies to students of the 2nd and 3rd year of general medicine and 3rd year of dental medicine. For motivated students, the department offers core elective subjects and the opportunity to participate in research projects and present the results at student conferences.

Pathological physiology I

Syllabus

Goals of teaching

Lectures

Practicals 

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class.

Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.

Credit

Conditions for the credit – Pathological physiology I:

1. Active attending practical exercises – 2 absences per semester are allowed.
For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class.

2. Submitting of correctly elaborated protocols of all experiments and practical exercises verified by the teacher.

Note:
Pathological physiology I is followed by pathological physiology II ending with a credit and exam.

Educational materials

Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.

Literature

Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathophysiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the webpage of the department or provided to students in printed or electronic form.

Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue


Pathological physiology II

Syllabus

Goals of teaching

Lectures

Practicals 

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class.

Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.

Credit

Conditions for the credit – Pathological physiology II:

  1. Active attending practical exercises – 2 absences per semester are allowed.

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (se study literature). Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology. Students, who did not attend the class in time, will be not admitted to the class.

  1. Submitting of correctly elaborated protocols of all experiments and practical exercises verified by the teacher.

The conditions of the credits for students having an individual study plan, who enrolled pathological physiology II for the second time, will be appointed individually in dependence on study duties passed in the previous academic year. These conditions will not exceed the range of above specified general duties. These students are required to contact the teacher of the relevant study group (see timetable in Practical exercises section on this web) at the beginning of the semester.

Educational materials

Education materials – text documents, presentations and annotated presentations are available on the MOODLE portal in the course Pathological Physiology I, II. It is possible to register for the course via a CAS account.

Exam

Conditions for the exam:
Pathological physiology II follows pathological physiology I. The required knowledge contains curriculum of both subjects pathological physiology I and pathological physiology II.

The student is obliged to register for the exam before the deadline using SIS (other ways of registration will not be accepted). Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination. The condition for registration for the exam is to obtain a credit in pathological physiology I and pathological physiology II.

The exam consists of a practical exam and oral exam. The required knowledge is based on the list of exam questions and the syllabus of the subjects Pathological Physiology I and Pathological Physiology II.

Practical exam consists of question related to practical exercises and ECG record analysis. Failure in the practical exam means classification of the exam “fail”.

Oral exam consists of 4 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 4 questions.

Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.

Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam “failed”, the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.

Standardly, the exam is on-site. In the case of the remote form of examination (if the circumstances do not allow for a standard examination and in accordance with the rules in force at the time of the exam), an interview will be conducted by Zoom, MS Teams or similar tool. It is therefore necessary for the student to be equipped with an internet connection, a computer with a camera and a microphone. In the case of remote examination, the questions will be selected by the teacher, the exam will start immediately after the questions have been asked and the student will not have time to prepare.

Literature

Mandatory literature:
Sobotka et al.: Pathophysiology – Laboratory Exercises. 2013, Karolinum, 2013
McPhee, Hammer et al.: Pathophysiology of Disease: An Introduction to Clinical Medicine. The McGraw-Hill Companies, Inc., 6th Edition 2010 (or later issues)
Educational materials of the Department of Pathophysiology published on educational portals of the Faculty of Medicine in Pilsen, Charles University or the webpage of the department or provided to students in printed or electronic form.

Recommended literature:
Hueher et al.: Understanding Pathophysiology. Elsevier, 2017
McCance and Huether: Pathophysiology, the Biologic Basis for Disease in Adults and Children. Elsevier, 2019
Banasik and Copstead: Pathophysiology. Elsevier, 2019
Hulín et al.: Pathophysiology. Slovak Academic Press, 1997 (or later issues)
Silbernagl and Lang: Color Atlas of Pathophysiology. 3rd edition, Georg Thieme Verlag KG, 2016
Price and Wilson et al.: Pathophysiology – Clinical concepts of disease processes. Mosby, Inc., 2003
Guyton: Human physiology and mechanisms of disease. W. B. Saunders Company, the latest issue

Pathological physiology – Dental Medicine

Syllabus

Lectures

Practicals Exercises

For the practical exercises, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (see study literature). Students, who did not attend the class in time, will be not admitted to the class with the sanction of absence.

Prerequisites are knowledge from the fields to which the subject pathological physiology follows, i.e. anatomy, histology, embryology, biology, genetics, chemistry and biochemistry, biophysics, physiology and microbiology.

Credits

Conditions for the credit :

1. Active attending practical exercise – 1 absences per semester are allowed.
For the practical exercises or seminars, the student must be theoretically prepared for the topic of the given class and is obliged to acquaint himself with the guideline for the given experiment or task (se study literature). Students, who did not attend the class in time, will be not admitted to the class.

2. Submitting of correctly elaborated protocols of all experiments and practical exercises to the teacher, who assesses their correctness and confirms them as fulfilled, or returns them for revision.

Exam

Conditions for the exam:

The student is obliged to register for the exam before the deadline using SIS (other ways of registration will not be accepted). Registration is necessary for the regular term as well as for potential 1st re-examination or 2nd re-examination. The condition for registration for the exam is to obtain a credit (if not specified differently for a particular exam date).

The exam consists of a practical exam and oral exam. The required knowledge is based on the list of exam questions and the syllabus of the subject.

Practical exam consists of question related to practical exercises. Failure in the practical exam means classification of the exam “fail”.

Oral exam consists of 3 questions. To pass the oral exam, the student must show sufficient knowledge in each of these 3 questions.

Final classification takes into consideration not only the performance in the oral exam but also the classification of the practical exam.

Practical and oral exams constitute one complex and cannot be separated into two examination terms. In the case of classification of any part of the exam “failed”, the student is subjected to both the practical and oral exam again in the 1st or 2nd reexamination.

Standardly, the exam is on-site. In the case of the remote form of examination (if the circumstances do not allow for a standard examination and in accordance with the rules in force at the time of the exam), an interview will be conducted by Zoom, MS Teams or similar tool. It is therefore necessary for the student to be equipped with an internet connection, a computer with a camera and a microphone. In the case of remote examination, the questions will be selected by the teacher, the exam will start immediately after the questions have been asked and the student will not have time to prepare.

Core elective subject

Brain – mechanisms and pathophysiology of its higher functions
Abstract:
You’ll learn about mechanisms of higher cognitive functions of the brain – learning and memory, sensory information processing, decision making, etc. The main impact of the course is on experimental neuroscience across its cellular and systems levels, and both on its basic and most recent achievements. Despite we’ll always look for the relevant clinical projections, the primary focus is scientific. The seminar will mainly build on your previous knowledges in neuroanatomy and neurophysiology.
Guarantor: Ježek Karel, M.D., Ph.D.
Literature:
Principles of Neural Science, Kandel et al., McGraw-Hill Education / Medical, 2012

Research

After the founding of the faculty in 1945, the activities of the staff of the institute consisted almost exclusively of teaching. From the beginning of the 1950s, research activities focused on higher nervous activity were started, and thus the future scientific profiling of the institute focused on experimental research of the nervous system was determined. Since the mid-1990s, research has focused on the pathophysiology of the cerebellum.

At present, the central point of the research focus remains the issue of cerebellar degeneration. Using several mouse models and more experimental approaches (behavioral, electrophysiological, histological, histo- and immunohistochemical methods), not only the pathogenetic mechanisms of these processes in various conditions (stress factors, enriched environment) are studied, but there is also an effort to find ways to influence them, for example with neuropharmaceuticals, growth factors and neurotransplantation. As part of this research, there is a long-term cooperation with a number of domestic and foreign laboratories. In recent years, the research activities of the department are linked with the scientific activities of the Biomedical Center.


Contact

Department of Pathophysiology
Charles University
Faculty of Medicine in Pilsen
alej Svobody 1655/76, building U2
32300 Pilsen
tel: + 420 377 593 360
e-mail: andrea.korandova@lfp.cuni.cz